Qualitative and Quantitative analysis of 3D predicted arachidonate 15-lipoxygenase-B (15-LOX-2) from Homo sapiens
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چکیده
منابع مشابه
Qualitative and Quantitative analysis of 3D predicted arachidonate 15-lipoxygenase-B (15-LOX-2) from Homo sapiens
15-Lipoxygenase-2 protein has been reported to play an important role in normal development of prostate, lung, skin, and cornea tissues. It behaves as a suppressor of prostate cancer development by restricting cell cycle progression and implicating a possible protective role against tumor formation. On the basis of the above report, we selected 15-LOX-2 protein to study the structural classific...
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Hugo: ALOX15 Other names: 15-LOX; EC 1.13.11.33; arachidonate omega 6-lipoxygenase; LOG15 Location: 17p13.3 Local order: Genes flanking ALOX15 in centromere to telomere direction on 17p13 are: MYBBP1A 17p13.3 MYB binding protein (P160) 1a, GGT6 17p13.2 homolog of gammaglutamyltransferase 6, LOC124974 17p13.2, thioredoxin 1 pseudogene 4, SMTNL2 17p13.2 smoothelin-like 2, ALOX15 17p13.2 arachidon...
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Inflammation in the vascular wall is important for development of atherosclerosis. We have shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly expressed in human atherosclerotic lesions than in healthy arteries. This enzyme oxidizes fatty acids to substances that promote local inflammation and is expressed in lipid-loaded macrophages (foam cells) present in the at...
متن کاملTumor-suppressing 15-Lipoxygenase-2
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ژورنال
عنوان ژورنال: Bioinformation
سال: 2012
ISSN: 0973-8894,0973-2063
DOI: 10.6026/97320630008555